NF-kB p65 (RELA) Mouse Monoclonal Antibody [Clone ID: 112A1021]
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Other products for "NF-kB p65"
Specifications
Product Data | |
Clone Name | 112A1021 |
Applications | FC, IHC, WB |
Recommended Dilution | Immunohistochemistry: 5 - 15 ug/mL, Western Blot: 2 - 5 ug/mL, Flow (Intracellular)), Immunohistochemistry-Paraffin: 5 ug/mL, Simple Western: 1:25, Immunoprecipitation, Flow Cytometry: 0.25 - 0.5 ug/10^6 cells, CyTOF-ready |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | This antibody was raised against a synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein. |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | RELA proto-oncogene, NF-kB subunit |
Database Link | |
Background | NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The active nuclear form of the NF-kB transcription factor complex is composed of two DNA binding subunits, NF-kB p65 and p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product. N-terminal regions of p50 and p65 are critical for DNA binding and help determine the DNA-binding specificities of p50 and p65. |
Synonyms | NFKB3; p65 |
Note | Western Blot and Flow cytometry/analysis (Intracellular) as reported in the literature (Wittmann et al, 2005). IHC (paraffin) as reported in the literature (Chang et al, 2005) |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway |
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