Gremlin 1 (GREM1) Rabbit Polyclonal Antibody

CAT#: TA336479

Rabbit Polyclonal Gremlin 1 Antibody

Product Images

Immunohistochemistry-Paraffin: Gremlin 1 Antibody TA336479 - Detection of Gremlin in human colon cancer tissue using antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry: 1:20-1:1000, Immunohistochemistry-Frozen), Immunohistochemistry-Paraffin: 2.5-10 ug/ml
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide containing amino acids QPGSRNRGRGQGRGTA (52-67) of human CKTSF1B1 (NM_013372).
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: gremlin 1, DAN family BMP antagonist
• Database Link:
  NP_037504
  Entrez Gene 26585 Human
  UniProt ID O60565
• Background: In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
• Synonyms: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
• Note: Immunohistochemistry cryosections reported in literature (See Namkoong et al, 2006 for antibody usage).

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Secreted Protein