Noggin (NOG) Rabbit Polyclonal Antibody

CAT#: TA336497

Rabbit Polyclonal Noggin Antibody

Product Images

Western Blot: Noggin Antibody TA336497 20ug of human hippocampus tissue lysate (lanes 2 and 4) with Noggin polyclonal at 1:1000 dilution followed by secondary at 1:5000 dilution MW marker Lane 1 peptide absorption control lane 3.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide comprising an internal sequence of the human Noggin protein. Sequence is 100% conserved in rat and mouse (NP_005441).
• Formulation: PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25.7 kDa
• Gene Name: noggin
• Database Link:
  NP_005441
  Entrez Gene 18121 MouseEntrez Gene 25495 RatEntrez Gene 9241 Human
  UniProt ID Q13253
• Background: Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
• Synonyms: SYM1; SYNS1; SYNS1A
• Note: This antibody is useful for Western Blot 1:1000-1:2000.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: TGF-beta signaling pathway