BIRC5 Rabbit Polyclonal Antibody

CAT#: TA336508

Rabbit Polyclonal Survivin Antibody

Product Images

Western Blot: Survivin Antibody TA336508 - analysis of Survivin in MOLT-4 lysate using this antibody at 1:1000 dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Reacts with residues 125-142 EETAKKVRRAIEQLAAMD of the human Survivin protein.
• Formulation: PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 16.4 kDa
• Gene Name: baculoviral IAP repeat containing 5
• Database Link:
  NP_001159
  Entrez Gene 332 Human
  UniProt ID O15392
• Background: Survivin is a human gene encoding a structurally unique IAP apoptosis inhibitor. Present during fetal development, survivin is undetectable in terminally differentiated adult tissues. However, survivin becomes prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas, prostate and breast, in vivo. Survivin is also found in high-grade non-Hodgkin's lymphomas. These data suggest that apoptosis inhibition may be a general feature of neoplasia and identify survivin as a potential new target for apoptosis-based therapy in cancer and lymphoma.
• Synonyms: API4; EPR-1
• Note: This antibody is useful for Western Blot 1:500-1:1000.

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Colorectal cancer, Pathways in cancer