TMP21 (TMED10) Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of transmembrane emp24-like trafficking protein 10 (yeast) (TMED10)
USD 396.00
Other products for "TMP21"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Immunohistochemistry: 1:100-1:200, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:100-1:200, Knockdown Validated |
Reactivities | Human, Mouse, Rat, Bovine, Chicken, Primate, Rabbit |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide made to an internal sequence of the human TMP21 protein (within residues 100-200). [Swiss-Prot# P49755] |
Formulation | PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Immunogen affinity purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 21 kDa |
Gene Name | transmembrane p24 trafficking protein 10 |
Database Link | |
Background | TMP21 (transmembrane protein Tmp21) is a type I transmembrane protein with large luminal domain belonging to p24 endoplasmic reticulum/Golgi cargo family and play key roles in protein transport, membrane structure organization and secretory pathway. TMP21 is ubiquitously expressed with highest protein levels observed in pancreas and intestines. In addition to its well established role in vesicle formation and cargo transport in ER/Golgi, TMP21 has been implicated in recruitment of small GTPase ADP-ribosylation factor 1 to Golgi apparatus and ADP-ribosylation factor 1-dependent assembly of actin in the Golgi. TMP21 forms a component of presenilin complex at the plasma membranes and modulates gamma -secretase cleavage. The cytoplasmic tails of p24 family interacts with coatomer (major component of coat protein complex I or COP-I), to facilitate transport between ER and Golgi. TMP21 cycles through the early secretory pathway between intermediate and cis-Golgi compartments, and is essential for proper organization of the Golgi apparatus. TMP21 also plays an essential and non-redundant role in earliest stages of mammalian development. |
Synonyms | p23; P24(DELTA); p24d1; S31I125; S31III125; Tmp-21-I; TMP21 |
Note | This TMP21 antibody is useful for Immunohistochemistry-Paraffin and Western blot analysis where a band is seen at ~21 kDa. |
Reference Data | |
Protein Families | Transmembrane |
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