CNPase (CNP) Rabbit Polyclonal Antibody

CAT#: TA336548

Rabbit Polyclonal CNPase Antibody

Product Images

CNPase Antibody TA336548 - WB detection of CNPase in 10ug of normal brain tissue lysate using CNPase antibody TA336548 at a dilution of 1:500

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:100-1:2000
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Reacts with residues 68-84 of the 46-48 (doublet) kDa human, CNPase protein (74% sequence identity and 94% sequence similarity to mouse and rat).
• Formulation: PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
• Database Link:
  NP_149124
  Entrez Gene 1267 Human
  UniProt ID P09543
• Background: CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.
• Synonyms: CNP1
• Note: This antibody is useful in Western Blot, ELISA and Immunohistochemistry