c Abl (ABL1) Rabbit Polyclonal Antibody

CAT#: TA336552

Rabbit Polyclonal c-Abl Antibody

Product Images

Western Blot: c Abl Antibody TA336552 - Detection of C-ABL in K562 whole cell lysate using TA336552.

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  Immunocytochemistry/Immunofluorescence: c Abl Antibody TA336552 - ICC/IF staining of c-Abl in U2OS cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 2 ug/ml, IF: 1:500 - 1:1000
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide made to an internal portion of human c Abl (within residues 700-800). [Swiss-Prot# P00519]
• Formulation: Tris-citrate/phosphate, pH 7, 0.1% Sodium azide. Store at 4C. Do not freeze.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 120 kDa
• Gene Name: ABL proto-oncogene 1, non-receptor tyrosine kinase
• Database Link:
  NP_009297
  Entrez Gene 11350 MouseEntrez Gene 25 Human
  UniProt ID P00519
• Background: c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. It localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Activity of the c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. c-ABL also potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
• Synonyms: ABL; abl; bcr; c-ABL; c-ABL1; JTK7; p150; v-abl
• Note: This c Abl antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~120 kDa. In ICC/IF cytoplasmic staining is observed in untreated cells.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Axon guidance, Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Viral myocarditis