Bcl x (BCL2L1) Rabbit Polyclonal Antibody

CAT#: TA336563

Rabbit Polyclonal Bcl-xL Antibody

Product Images

Western Blot: Bcl-Xl Antibody TA336563 - Detection of BCL2L1 / Bcl-Xl in whole cell lysate of A431 cell line using TA336563.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:10000
• Reactivities: Human, Mouse, Rat, Canine, Feline, Hamster, Porcin
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide made to an N-terminal portion of human BCL2L1 (within residues 1-50). [Swiss-Prot# Q07817]
• Formulation: Tris-citrate/phosphate, pH 7, 0.1% Sodium azide. Store at 4C. Do not freeze.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26 kDa
• Gene Name: BCL2 like 1
• Database Link:
  NP_612815
  Entrez Gene 12048 MouseEntrez Gene 24888 RatEntrez Gene 598 Human
  UniProt ID Q07817
• Background: BCL2L1 (BCL2-like 1) is a member of BCL-2 protein family and proteins encoded by this gene are located at the outer mitochondrial membrane, where they have been shown to control outer mitochondrial membrane channel (VDAC) opening. VDAC has the ability to regulate mitochondrial membrane potential which is critical to regulation of ROS production as well as release of cytochrome c by mitochondria, both of which are the potent inducers of cellular apoptosis. BCL2L1 also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. There are two alternatively spliced transcript variants, which encode distinct isoforms, and the longer isoform Bcl-X(L) acts as an apoptotic inhibitor whereas the shorter form Bcl-Xl acts as an apoptotic activator. Bcl-X(S) is expressed at high levels in cells undergoing high rate of turnover, such as developing lymphocytes. In contrast, Bcl-Xl is found in tissues containing long-lived postmitotic cells, such as adult brain.
• Synonyms: Bcl-X; BCL-XL; BCL2L; BCLX; PPP1R52; S
• Note: This BCL2L1 antibody is useful for Western blot, where a band is seen ~26 kDa. This antibody is not useful for ICC/IF.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Apoptosis, Chronic myeloid leukemia, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer