Niemann Pick C1 (NPC1) Rabbit Polyclonal Antibody

CAT#: TA336646

Rabbit Polyclonal Niemann-Pick C1 Antibody


USD 457.00

5 Days*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry: 5-10 ug/ml, Immunohistochemistry-Paraffin: 5-10 ug/ml, Knockdown Validated, Knockout Validated, Electron Microscopy, Immunocytochemistry/ Immunofluorescence: 1:250, Western Blot: 1:1000-1:3000, Immunoprecipitation: 1:10-1:500
Reactivities Human, Mouse, Rat, Porcine, Hamster, Primate
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to the C-terminal region of human Niemann-Pick C. [UniProt# O15118]
Formulation PBS, 0.1% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name NPC intracellular cholesterol transporter 1
Background Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. NPC1 protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.
Synonyms NPC
Note This Niemann-Pick C1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections, Immunoprecipitation and Western blot. In Western blot the antibody detects heterogeneously glycosylated NPC1 protein with prominent bands at 170 and 220 kDa. It has also been tested for immuno-EM (on human protein only). Use in Electron Microscopy reported in scientific literature (PMID: 21051527)
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Lysosome

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