Bcl2 Binding component 3 (BBC3) Rabbit Polyclonal Antibody

CAT#: TA336662

Rabbit Polyclonal PUMA Antibody

Product Images

Western Blot: PUMA Antibody TA336662 - WB detection of PUMA in transfected U20S cells using TA336662 at a dilution of 1:250. Please note that this antibody is expected to detect alpha as well as the beta forms of this target.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:250 -1:1000
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: BCL2 binding component 3
• Database Link:
  NP_055232
  Entrez Gene 27113 Human
  UniProt ID Q96PG8
• Background: A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
• Synonyms: JFY-1; JFY1; PUMA
• Note: This antibody can be used in western blot, where the predicted molecular weight is 20 kDa.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease, p53 signaling pathway