TRAF5 Mouse Monoclonal Antibody [Clone ID: 55A219]

CAT#: TA336671

Mouse Monoclonal TRAF-5 Antibody (55A219)


USD 424.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Clone Name 55A219
Applications WB
Recommended Dilution Western Blot: 2 ug/ml
Reactivities Human
Host Mouse
Isotype IgG
Clonality Monoclonal
Immunogen Anti-TRAF5 monoclonal antibody was raised against a fusion protein corresponding to amino acids 77 to 186 of human TRAF5.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name TNF receptor associated factor 5
Background Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation.
Synonyms MGC:39780; RNF84
Note This antibody can be used in Western Blot where a 66 kDa band is seen (predicted molecular weight 66.8 kDa).
Reference Data
Protein Families Druggable Genome
Protein Pathways Pathways in cancer, Small cell lung cancer

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