IKAP (IKBKAP) Rabbit Polyclonal Antibody

CAT#: TA336679

Rabbit Polyclonal IKBKAP Antibody

Product Images

Western Blot: IKBKAP Antibody TA336679 - Analysis of IKBKAP in Interleukin-1-stimulated 293 cells using this antibody at 1:500 dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500 -1:1000
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acid residues 148-161 IHQDDFGESKFITV of human IKAP. Cross reactivity: sequence 92% identical to rat and 85% identical to mouse.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 158 kDa
• Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
• Database Link:
  NP_003631
  Entrez Gene 8518 Human
  UniProt ID O95163
• Background: The transcription factor NF-kappa B coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappa B is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes. Theses large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for 3 different kinases involved in pro-inflammatory cytokine signaling.
• Synonyms: DYS; ELP1; FD; IKAP; IKI3; TOT1
• Note: However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Reference Data

• Protein Families: Druggable Genome