FANCC Rabbit Polyclonal Antibody

CAT#: TA336732

Rabbit Polyclonal FANCC Antibody

Product Images

Western Blot: FANCC Antibody TA336732 - Western Blot on cells overexpressing FANCC probed with 1. pre-immune serum and 2.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Western Blot: 1:500-1:1000, Immunoprecipitation: 1:10-1:500
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal human FANCC fusion protein [Swiss-Prot #Q00597].
• Formulation: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 63 kDa
• Gene Name: Fanconi anemia complementation group C
• Database Link:
  NP_000127
  Entrez Gene 2176 Human
  UniProt ID Q00597
• Background: FANCC (Fanconi anemia group C protein) is a DNA repair protein which implicates in post-replication DNA repair or a cell cycle checkpoint function. FANCC also involves in the interstrand DNA cross-link repair as well as the maintenance of chromosome stability/integrity. FANCC participates in the multisubunit FA complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and HSP70) which is not found in FA patients. Upon IFNG induction, FANCC facilitate STAT1 activation via recruitement of STAT1 to IFNGR1. FANCC interacts with ZBTB32 (upon IFNG induction), CDK1, STAT1 etc and FANCC-EIF2AK2 interactions leads to augmented EIF2AK2 activation and cell death. FANCC is expressed ubiquitously and the major form is nuclear while the minor form is cytoplasmic. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC), disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
• Synonyms: FA3; FAC; FACC
• Note: This FANCC antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot where a band is seen ~63 kDa.

Reference Data

• Protein Families: Druggable Genome