alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 24.8]

CAT#: TA336747

Mouse Monoclonal Synuclein-alpha [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8)


USD 535.00

5 Days*

Size
    • 100 ul

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Specifications

Product Data
Clone Name 24.8
Applications FC, WB
Recommended Dilution WB: 1:500-1:1500, FC: 1 ug per million cells, IF: , IHC: 1:200-1:500, IHC-F: , IHC-P: 1:200-1:500
Reactivities Human, Mouse
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Nitrated human alpha-Synuclein [UniProt# P37840]
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 14 kDa
Gene Name synuclein alpha
Background alpha-Synuclein (SNCA, NACP or PARK-1) is a neuronal protein normally localized to presynaptic terminals and has been involved in processes such as dopamine biosynthesis, synaptic plasticity, and vesicle dynamics. SNCA-VAMP2 direct binding promotes SNARE complex assembly through a nonclassical chaperone activity and regulation of SNARE complex's assembly/disassembly is essential for efficient neurotransmission. CSP-alpha, a presynaptic protein also promotes SNARE complex assembly via formation of chaperone complex with heat shock cognate 70 (Hsc70) and small glutamine-rich protein SGT (CSP-alpha-Hsc70-SGT complex). Interestingly, the CSP-alpha-knockout mice depicted rapidly progressive neurodegeneration followed by premature death which was counteracted by transgenic expression of SNCA. Overexpressed SNCA indirectly inhibited SNARE-mediated exocytosis by sequestering arachidonic acid, which upregulates syntaxin and enhances its engagement with SNARE complex. Tight regulation of subcellular level and distribution of SNCA is indispensable for the intrinsic functions of neuronal cells and genetic alterations of SNCA resulting in aberrant polymerization into fibrils are associated with several neurodegenerative diseases (synucleinopathies) including Parkinson disease type -1 (PARK1) - 4 (PARK4) as well as dementia Lewy body (DLB).
Synonyms NACP; PARK1; PARK4; PD1
Note This alpha-Synuclein antibody is useful for for Flow Cytometry, Immunohistochemisty paraffin embedded sections and Western blot, where a band is seen at ~14 kDa. Immunohistochemistry-Frozen was reported in scientific literature. Use in Immunofluorescence was reported in the scientific literature (PMID: 22033456).
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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