LGR5 Rabbit Polyclonal Antibody

CAT#: TA336750

Rabbit Polyclonal Lgr5/GPR49 Antibody


USD 479.00

2 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications IHC
Recommended Dilution Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry-Frozen, Immunocytochemistry/ Immunofluorescence: 2-5 ug/ml, Western Blot: 1.0-2.0 ug/ml, Flow (Intracellular), Immunohistochemistry: 1:200
Reactivities Human, Porcine
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide made to an internal portion of the human GPR49/LGR5 protein (within residues 650-700). [Swiss-Prot# O75473]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name leucine-rich repeat containing G protein-coupled receptor 5
Background GPR49/LGR5 (G protein-coupled receptor 49 / leucine-rich repeat-containing G protein-coupled receptor 5), also called FEX, GPR67, GRP49, HG38 or MGC117008), is structurally related to members of glycoprotein hormone receptor family including FSH-R, TSH-R and LH-R. LGRs (leucine-rich repeat-containing G-protein coupled receptor) are divided into three major subgroups: glycoprotein hormone receptors; the subgroup of GPR48, GPR49, and LGR6; and receptors of relaxin family ligands (LGR7 and LGR8), of which GPR49 is emerging as a significant player in stem cells biology as it is highly expressed on stem cells in small intestine, colon and hair follicle. Deficiency of GPR49 in mice has been shown to cause neonatal lethality characterized by ankyloglossia, gastrointestinal distension and induction of premature differentiation of Paneth cells. LGR5 is a downstream target gene of Wnt signaling pathway (critical for morphogenesis and tumorigenesis) and it has also been reported as a receptor for R-spondins which are potent mediators of Wnt/beta-catenin as well as Wnt/PCP signaling. Accordingly, when compared to normal tissues, LGR5 is found upregulated in certain cancers e.g liver cancer with beta-catenin mutations, basal cell carcinoma, colon and ovarian carcinomas.
Synonyms FEX; GPR49; GPR67; GRP49; HG38
Note This GPR49/LGR5 antibody is useful for Immunohistochemistry on paraffin-embedded sections and Western blot. This antibody is not recommended for Immunocytochemistry/Immunofluorescence.
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.