KCNC1 Rabbit Polyclonal Antibody

CAT#: TA336758

Rabbit Polyclonal Potassium Channel Kv3.1 Antibody

Product Images

Western Blot: Kv3.1 Antibody TA336758 - Membrane preparations from HEK-293 cells untransfected (lane 1), transfected with Kv3.1 (lanes 2 and 4) and transfected with Kv1.2 (lane 3) were subjected to SDS-PAGE and were Western blotted with Kv3.1 Antibody (

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000, Blocking/Neutralizing 50-200 molar excess, IP: 1:10-1:500
• Reactivities: Bovine, Canine, Human, Mouse, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide made to an internal portion of rat Kv3.1 (within residues 350-400). [Swiss-Prot# P25122]
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 110 kDa
• Gene Name: potassium voltage-gated channel subfamily C member 1
• Database Link:
  NP_004967
  Entrez Gene 16502 MouseEntrez Gene 25327 RatEntrez Gene 3746 Human
  UniProt ID P48547
• Background: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
• Synonyms: EPM7; KV3.1; KV4; NGK2
• Note: This Kv3.1 antibody is useful for Blocking/Neutralizing, Western blot and Immunoprecipitation. In WB a band can be seen at ~110 kDa.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane