Calreticulin (CALR) Mouse Monoclonal Antibody [Clone ID: 1G6A7]

CAT#: TA336776

Mouse Monoclonal Calreticulin Antibody (1G6A7)


USD 457.00

2 Weeks*

Size
    • 100 ul

Frequently bought together (3)
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Specifications

Product Data
Clone Name 1G6A7
Applications FC, IHC, WB
Recommended Dilution Immunohistochemistry: 1:200 - 1:1000, Immunohistochemistry-Paraffin: 1:200 - 1:1000, ELISA: 1:1000, Flow Cytometry: 1 ug/ml, Flow (Intracellular): 1 ug/ml, In vitro assay, Western Blot: 1:500 - 1:2000, Immunocytochemistry/ Immunofluorescence: 1:200 - 1:1000
Reactivities Human, Mouse
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to the C-terminus (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH. [UniProt# P27797]
Formulation PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Ammonium sulfate precipitation
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 48 kDa
Gene Name calreticulin
Background Calreticulin is the major calcium binding protein found in smooth muscle sarcoplasmic reticulum (SR) and non-muscle endoplasmic reticulum (ER) membranes. This protein was originally identified in SR membranes and plays a minor role in calcium storage in skeletal and cardiac muscle SR. Calreticulin is also known as calregulin, CRP55, CaBP3, calsequestrin-like protein and Ro/SS-A antigen. Calreticulin binds calcium with low affinity and high capacity, however, it also exhibits a single high affinity binding site. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of calreticulin and other resident ER proteins including glucose regulated protein 78 (GRP78), GRP94 and protein disulfide isomerase (PDI). This sequence is responsible for the retention of newly synthesized proteins within the ER lumen. This retention is reported to be mediated by a KDEL receptor. Recent reports indicate that calreticulin can act as a modulator of the regulation of gene transcription by nuclear hormone receptors and may also act as a molecular chaperone.
Synonyms cC1qR; CRT; HEL-S-99n; RO; SSA
Note This Calreticulin (1G6A7) antibody is useful in Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and ELISA.
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transcription Factors
Protein Pathways Antigen processing and presentation

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.