SLITRK1 Rabbit Polyclonal Antibody

CAT#: TA336791

Rabbit Polyclonal SLITRK1 Antibody

Product Images

Immunohistochemistry: Slitrk1 Antibody TA336791 - Analysis of Slitrk1 in mouse prostate

• 

  Western Blot: Slitrk1 Antibody TA336791 - Analysis of Slitrk1 in human brain lysate.

• 

  Western Blot: Slitrk1 Antibody TA336791 - Analysis of Slitrk1 in mouse brain lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry: 1:250, Western Blot: 1:2500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A genomic peptide made to an internal region of the human Slitrk1 protein (within residues 250-400). [Swiss-Prot Q96PX8]
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SLIT and NTRK like family member 1
• Database Link:
  NP_001268432
  Entrez Gene 76965 MouseEntrez Gene 114798 Human
  UniProt ID Q96PX8
• Background: SLITRK1 (SLIT- and TRK-like family, member 1) is a type I transmembrane protein with an extracellular LRR (leucine-rich repeat) domain homologous to SLIT and a short intracellular domain lacking tyrosine phosphorylation motifs common among other SLITRK family members. SLITRK1 has been implicated in certain pathologies including Gilles de la Tourette syndrome (GTS) and trichotillomania (TTM). SLITRK1 has been shown to interact with 14-3-3 proteins, which are ubiquitously expressed phosphorylation-binding proteins implicated in regulation of multiple vital cellular processes such as proliferation, neuronal migration and membrane excitability. SLITRK1 has been shown to control neurite outgrowth and is expressed in embryonic as well as postembryonic brain with highest expression in cortex, thalamus and basal ganglia. SLITRK1 has also been reported to express in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
• Synonyms: LRRC12; TTM
• Note: This Slitrk1 antibody is useful for IHC and Western blot. In Western blot a band is seen ~83 kDa.

Reference Data

• Protein Families: Transmembrane