JMJD6 Rabbit Polyclonal Antibody

CAT#: TA336815

Rabbit Polyclonal JMJD6/PSR Antibody


USD 424.00

5 Days*

Size
    • 50 ul

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Western Blot: 1:2000
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen A genomic peptide made to an internal region of the human JMJD6 protein (within residues 150-350). [Swiss-Prot Q6NYC1]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name arginine demethylase and lysine hydroxylase
Background Jumonji domain containing 6 is a histone demethylating enzyme, which is active on arginine residues, but not lysines. Its activity destabilizes heterochromatin structures and activates gene expressions in euchromatin. In endothelial cells, the activity of JMJD6 is necessary for angiogenesis. If JMJD6 expression is reduced, the VEGF-receptor (Flt-1) is incorrectly spliced, leading to increased soluble Flt-1 which binds VEGF and PlGF and inhibits angiogenesis. JMJD6 also hydroxylates RNA splicing factors, and is important in embryonic differentiation. It most likely interacts specifically with single-stranded RNA, which may contribute to its early differentiation importance.
Synonyms PSR; PTDSR; PTDSR1
Note This JMJD6 antibody is useful for ICC and Western Blot, where a band is seen ~45 kDa.
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.