GABARAP Rabbit Polyclonal Antibody

CAT#: TA336818

Rabbit Polyclonal GABARAP Antibody


USD 424.00

5 Days*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications IHC
Recommended Dilution Immunohistochemistry: 1:200, Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin: 1:200
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to a C-terminal region of the human GABARAP protein (within residues 50-117). [Swiss-Prot O95166]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name GABA type A receptor-associated protein
Background In several neurological diseases, GABARAP expression is related to autophagic functions. In Lewy body disease and Parkinson's disease, LC3 and GABARAP are often co-localized. Autophagy is regulated both at the transcriptional and post-transcriptional level, partially by the activation of GABARAP and other core autophagy machinery proteins. Although autophagy is usually considered to be important in cellular maintenance, and breakdown of proteins and organelles in cell death, it is becoming more and more clear that it plays an important role in the developmental process, including embryogenesis. This embryological effect seems to be partly regulated by GABARAP expression and activity.
Synonyms ATG8A; GABARAP-a; MM46
Note This GABARAP antibody is useful for ICC/IF and IHC-P. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Reference Data
Protein Families Druggable Genome
Protein Pathways Regulation of autophagy

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.