Collagen I (COL1A1) Rabbit Polyclonal Antibody

CAT#: TA336831

Rabbit Polyclonal Collagen I alpha 1 Antibody

Product Images

Immunocytochemistry/Immunofluorescence: Collagen I alpha 1 Antibody TA336831 - Collagen 1 antibody was tested in HeLa cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

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  Immunohistochemistry: Collagen I alpha 1 Antibody TA336831 - Analysis of Collagen 1 in mouse epidermis using DAB with hematoxylin counterstain.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Western Blot (Negative), Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry: 1:200, Immunocytochemistry/ Immunofluorescence: 10 - 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to the C-terminal portion of the human Collagen I protein (between residues 1300-1350) [UniProt P02452]
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: collagen type I alpha 1
• Database Link:
  NP_000079
  Entrez Gene 12842 MouseEntrez Gene 1277 Human
  UniProt ID P02452
• Background: Collagen-1 (also known as collagen alpha, COL1A1, and alpha-1 type I collagen) is the largest component of fibrillar collagen found in cartilage and connective tissues, and synthesizes by fibroblasts, osteoblasts, and odontoblasts. Trimers are formed by combing two alpha one chains and one alpha 2 chain. Mutations of the gene are found in Ehlers-Danlos syndrome, as well as osteogenesis imperfecta. Over 50 mutations have been found in these diseases, including deletions, insertions, splice variants, and substitutions.
• Synonyms: EDSC; OI1; OI2; OI3; OI4
• Note: This Collagen 1 antibody is useful for IHC-paraffin embedded sections.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion