TNFAIP3 Mouse Monoclonal Antibody [Clone ID: 59A426]

CAT#: TA336834

Mouse Monoclonal A20/TNFAIP3 Antibody (59A426)


USD 479.00

5 Days*

Size
    • 100 ug

Frequently bought together (2)
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Specifications

Product Data
Clone Name 59A426
Applications FC, IHC, WB
Recommended Dilution Flow Cytometry: 2.5 ug/ml, Immunohistochemistry-Paraffin: 5 - 10 ug/ml, Flow (Intracellular): 2.5 ug/ml, Western Blot: 2-4 ug/ml, Immunoprecipitation: 1-2 ug/ml, Immunocytochemistry/ Immunofluorescence: 10 ug/ml, Immunohistochemistry: 5 - 10 ug/ml, Simple Western: 1:100, CyTOF-ready
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Full length recombinant human A20. The epitope has been mapped to the C-terminal portion of A20 (amino acids 440-790)
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name TNF alpha induced protein 3
Background A20 (TNFAIP3) is an important regulator of proinflammatory signaling pathways, including NK-kB sginaling. A20 is upregulated through NF-kB (p50/p55) activation, and subsequently down regulates NF-kB through its dual function as a deubiquitinase and ubiquitin ligase (Evans, 2005). The A20 monoclonal antibody (clone 59A426) has been instrumental in discovering various nuances of NF-kB regulation and key to defining A20 biology.
Synonyms A20; OTUD7C; TNFA1P2
Note The A20 antibody (clone 59A426) has also been used in Immunohistochemistry-Paraffin (Metellus, 2010) and Flow Cytometry (intracellular) (Hjelmeland, 2010). Multiple A20 cleavage fragments have been described in Western Blot, see Coornaert (2008) and Hailfinger (2009) for additional details.
Reference Data
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.