TMS1 (PYCARD) Rabbit Polyclonal Antibody

CAT#: TA336850

Rabbit Polyclonal ASC/TMS1 Antibody


USD 479.00

5 Days*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution Flow (Intracellular): 1 - 2 ug/ml, Immunomicroscopy, Flow Cytometry: 1 - 2 ug/ml, Immunoprecipitation, Western Blot: 2.0 - 4.0 ug/ml, Simple Western: 1:1000, Immunohistochemistry: 1:400, Immunohistochemistry-Paraffin: 1:400, Immunocytochemistry/ Immunofluorescence: 1:40-1:100
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an N-terminal portion of the human ASC/TMS1 protein (between residues 1-50) [UniProt Q9ULZ3]
Formulation PBS with 30% Glycerol, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name PYD and CARD domain containing
Background Target of methylation-induced silencing 1 protein, TMS1 (ASC, Pycard) is a 21 kDa cytoplasmic adaptor protein containing 2 protein-protein interaction domains: an N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). Both domains are members of the six-helix bundle death domain superfamily. These domains, via caspase activation, mediate the assembly of large signaling complexes that are involved in the apoptotic and inflammatory signaling pathways. During apoptosis TMS1 aggregates near the nuclear periphery as ball-like structures. Recent research suggests that it can modulate MAPK expression by suppressing the DUSP10/MKP5 phosphatase thus allowing the phosphorylation of MAPK by pathogens and toll-like receptor agonists. PMID: 2148701.
Synonyms ASC; CARD5; TMS; TMS-1; TMS1
Note This ASC/TMS1 antibody is useful for Immunocytochemistry/Immunofluorescence and IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not recommended for Western Blot.
Reference Data
Protein Families Druggable Genome
Protein Pathways Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.