EBI3 Rabbit Polyclonal Antibody

CAT#: TA336876

Rabbit Polyclonal IL-27/IL-35 EBI3 Subunit Antibody

Product Images

Western Blot: EBI3 Antibody TA336876 - Analysis of EBI3 using TA336876 in 1) Daudi cell lysate using 2.0 ug/ml, 2) Ramos cell lysate at 2.0 ug/ml in the absence of immunizing peptide 3) Ramos cell lysate at 2.0 ug/ml in the presence of immunizing peptid

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 2-6 ug/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 50-100 of human EBI3 was used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Epstein-Barr virus induced 3
• Database Link:
  NP_005746
  Entrez Gene 50498 MouseEntrez Gene 10148 Human
  UniProt ID Q14213
• Background: EBI3 is a novel hematopoietin receptor family member related to the p40 subunit of interleukin-12 and to the ciliary neurotrophic factor receptor. It's expression is induced in B lymphocytes by Epstein-Barr virus (EBV) infection. Human EBI3 gene maps to chromosome 19p13.3, near genes encoding the erythropoietin receptor and the cytokine receptor-associated kinase, Tyk2. The protein is expressed in vivo by scattered cells in interfollicular zones of tonsil tissue, by cells associated with sinusoids in perifollicular areas of spleen tissue, and at very high levels by placental syncytiotrophoblasts. EBI3 expression in vitro is induced in EBV-negative cell lines by expression of the EBV latent infection membrane protein-1 and in peripheral blood mononuclear cells by pokeweed mitogen stimulation. The protein plays a crucial role in regulating cell-mediated immune responses.
• Synonyms: IL-27B; IL27B

Reference Data

• Protein Families: Druggable Genome, Secreted Protein