TLR3 Rabbit Polyclonal Antibody

CAT#: TA337079

Rabbit Polyclonal TLR3 [p Tyr759] Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 0.1 - 1.0 ug/mL, Immunocytochemistry/ Immunofluorescence: 1:10 - 1:2000, Immunohistochemistry-Frozen: 1:10 - 1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 750-800, containing a phosphorylated tyrosine residue at position 759, of human TLR3 was used as the immunogen.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 3
• Database Link:
  NP_003256
  Entrez Gene 142980 MouseEntrez Gene 7098 Human
  UniProt ID O15455
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa (4). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
• Synonyms: CD283; IIAE2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway