TLR2 Rat Monoclonal Antibody [Clone ID: 11G5]

CAT#: TA337143

Rat Monoclonal TLR2 Antibody (11G5)


USD 402.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Clone Name 11G5
Applications FC, WB
Recommended Dilution Western Blot: 4-6ug/ml~, Flow Cytometry: 2.5ug/10^6cells, CyTOF-ready
Reactivities Mouse
Host Rat
Isotype IgG2a, kappa
Clonality Monoclonal
Immunogen A portion of amino acids 400-450 of murine TLR2 was used as the immunogen for this antibody.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name toll like receptor 2
Background The Toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ Nk cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).
Synonyms CD282; TIL4
Note This monoclonal antibody only very weakly detects human TLR2 in Ramos cell lysate and is not recommended for human sample testing.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.