TLR7 Mouse Monoclonal Antibody [Clone ID: 4G6]

CAT#: TA337157

Mouse Monoclonal TLR7 Antibody (4G6)


USD 424.00

5 Days*

Size
    • 100 ug

Frequently bought together (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 159.00

Other products for "TLR7"

Specifications

Product Data
Clone Name 4G6
Applications FC, WB
Recommended Dilution Western Blot: 10ug/ml~, Flow Cytometry: 1-2ug/10^6cells, Flow (Intracellular): 5 ug/ml, Knockout Validated, CyTOF-ready, Immunocytochemistry/ Immunofluorescence: 1:500-1:5000, Immunohistochemistry: 1:50 - 1:200, Knockdown Validated
Reactivities Human, Mouse
Host Mouse
Clonality Monoclonal
Immunogen A partial human TLR7 recombinant protein (amino acids 562-839) was used as the immunogen. 277 amino acid ( AA 562- 839)~
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name toll like receptor 7
Background TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Synonyms TLR7-like
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.