IL33 Mouse Monoclonal Antibody [Clone ID: 6H496]

CAT#: TA337187

Mouse Monoclonal IL-33 Antibody (6H496)

Product Images

Western Blot: IL33 Antibody (6H496) TA337187 - Analysis of IL-33 using IL-33 monoclonal antibody in A. HUVEC cell lysate at 10 ug/ml and B. partial recombinant IL-33 (amino acids 112-270) at 1 ug/ml. Goat anti-mouse Ig HRP secondary antibody.

Specifications

Product Data

• Clone Name: 6H496
• Applications: WB
• Recommended Dilution: WB: 1-10 ug/ml
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: A partial recombinant human IL-33 (amino acids 112-270) protein was used as immunogen for this antibody.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C. Do not freeze.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 33
• Database Link:
  NP_254274
  Entrez Gene 90865 Human
  UniProt ID O95760
• Background: IL-33 is a 270 amino acid highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. It is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. It is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta.
• Synonyms: C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV

Reference Data

• Protein Families: Secreted Protein
• Protein Pathways: Cytosolic DNA-sensing pathway