WHIP (WRNIP1) Rabbit Polyclonal Antibody

CAT#: TA341610

Rabbit Polyclonal Anti-WRNIP1 Antibody

Product Images

WB Suggested Anti-WRNIP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate

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  Sample Type: HeLa cell lysateDilution: 1:1000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-WRNIP1 antibody: synthetic peptide directed towards the N terminal of human WRNIP1. Synthetic peptide located within the following region: PGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPT
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 72 kDa
• Gene Name: Werner helicase interacting protein 1
• Database Link:
  NP_569079
  Entrez Gene 56897 Human
  UniProt ID Q96S55
• Background: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects inThe Werner syndrome ATP-dependent helicase gene (WRN).The protein encoded byThis gene interacts withThe exonuclease-containing N-terminal portion ofThe Werner protein.This protein has a ubiquitin-binding zinc-finger domain inThe N-terminus, an ATPase domain, and two leucine zipper motifs inThe C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human.This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increasesThe initiation frequency of DNA polymerase delta-mediated DNA synthesis.This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated forThis gene. [provided by RefSeq, Jul 2012]
• Synonyms: bA420G6.2; WHIP
• Note: Immunogen Sequence Homology: Dog: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Zebrafish: 85%; Pig: 79%; Bovine: 79%; Yeast: 77%