Plakophilin 2 (PKP2) Rabbit Polyclonal Antibody

CAT#: TA342219

Rabbit polyclonal Anti-PKP2 Antibody

Product Images

WB Suggested Anti-PKP2 Antibody ; Positive Control: Lane 1-4: 20ug mouse keratinocyte lysate; Primary Antibody Dilution : 1:1000; Secondary Antibody : Anti-rabbit-HRP; Secondry Antibody Dilution : 1:6000;

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  WB Suggested Anti-PKP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: COLO205 cell lysatePKP2 is supported by BioGPS gene expression data to be expressed in COLO205

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-PKP2 antibody: synthetic peptide directed towards the N terminal of human PKP2. Synthetic peptide located within the following region: HPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPP
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 93 kDa
• Gene Name: plakophilin 2
• Database Link:
  NP_001005242
  Entrez Gene 67451 MouseEntrez Gene 5318 Human
  UniProt ID Q99959
• Background: This gene encodes a member ofThe arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments inThe cytoskeleton.This gene product may regulateThe signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity toThis locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
• Synonyms: ARVD9
• Note: Immunogen Sequence Homology: Human: 100%; Horse: 86%; Mouse: 86%; Dog: 79%; Rat: 77%; Bovine: 77%

Reference Data

• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC)