HMGN3 Rabbit Polyclonal Antibody

CAT#: TA343180

Rabbit Polyclonal Anti-HMGN3 Antibody

Product Images

Host: Rabbit; Target Name: Hmgn3; Sample Tissue: Mouse Small Intestine lysates; Antibody Dilution: 1.0 ug/ml

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Hmgn3 antibody is: synthetic peptide directed towards the middle region of Mouse Hmgn3. Synthetic peptide located within the following region: SKPRKTSAKKEPGTKISRGAKGKKEEKQEAGEEGTAPSANGDTKVEEAQR
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 11 kDa
• Gene Name: high mobility group nucleosomal binding domain 3
• Database Link:
  NP_004233
  Entrez Gene 94353 Mouse
  UniProt ID Q15651
• Background: Hmgn3 binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. It affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion, regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors and regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. It may play a role in ocular development and astrocyte function.
• Synonyms: PNAS-24; PNAS-25; TRIP7
• Note: Immunogen Sequence Homology: Human: 100%; Rabbit: 100%; Dog: 93%; Pig: 93%; Rat: 93%; Horse: 93%; Mouse: 93%; Bovine: 93%; Guinea pig: 79%

Reference Data

• Protein Families: Druggable Genome