PGC1 alpha (PPARGC1A) Rabbit Polyclonal Antibody

CAT#: TA343708

Rabbit Polyclonal Anti-PPARGC1A Antibody

Product Images

PPARGC1A antibody - N-terminal region validated by WB using transfected SH-SY5Y lysate at 1: 15000.

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  PPARGC1A antibody - N-terminal region validated by WB using Transfected Melanoma Cell at 1: 1000.

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  Lanes: Lane 1: 30 ug Human liver; Lane 2: 30 ug Rat liver; Lane 3: 30 ug Mouse (wild-type) liver; Lane 4: 30 ug Mouse [AMPK alpha 1/2 (-/-)] liver; Lane 5: 30 ug Human muscle; Lane 6: 30 ug Rat muscle; Lane 7: 30 ug Mouse muscle; Primary Antibody Dilution: 1: 100

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  WB Suggested Anti-PPARGC1A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: ACHN cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-PPARGC1A antibody: synthetic peptide directed towards the N terminal of human PPARGC1A. Synthetic peptide located within the following region: MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDS
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 91 kDa
• Gene Name: PPARG coactivator 1 alpha
• Database Link:
  NP_037393
  Entrez Gene 19017 MouseEntrez Gene 83516 RatEntrez Gene 10891 Human
  UniProt ID Q9UBK2
• Background: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
• Synonyms: LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1
• Note: Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Goat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Guinea pig: 100%; Zebrafish: 90%

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, Huntington's disease, Insulin signaling pathway