KDM6B Rabbit Polyclonal Antibody

CAT#: TA345640

Rabbit Polyclonal Anti-JMJD3 Antibody

Product Images

WB Suggested Anti-JMJD3 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate

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  Host: Rabbit; Target Name: JMJD3; Sample Tissue: HepG2; Lane A: Primary Antibody; Lane B: Primary Antibody + Blocking Peptide; Primary Antibody Concentration: 2.5 ug/mL; Peptide Concentration: 2.0 ug/mL; Lysate Quantity: 25 ug/lane; Gel Concentration: 6%-18%

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-JMJD3 antibody: synthetic peptide directed towards the middle region of human JMJD3. Synthetic peptide located within the following region: AGLQGVVVLEQYRTEELAQAYDAFTLVRARRARGQRRRALGQAAGTGFGS
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 70 kDa
• Gene Name: lysine demethylase 6B
• Database Link:
  NP_001073893
  Entrez Gene 23135 Human
  UniProt ID O15054
• Background: JMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
• Synonyms: JMJD3
• Note: Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%