Angiotensin Converting Enzyme 1 (ACE) Mouse Monoclonal Antibody [Clone ID: 4F3-E6-H8]

CAT#: TA346871

Mouse Monoclonal Angiotensin Converting Enzyme 1 Antibody

Product Images

Western blot detection of Angiotensin Converting Enzyme 1 in Mouse kidney cell lysates using Angiotensin Converting Enzyme 1 mouse mAb (1:1000 diluted).Predicted band size:150KDa.Observed band size:190KDa.

Specifications

Product Data

• Clone Name: 4F3-E6-H8
• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: The immunogen for ACE antibody: purified recombinant human Angiotensin Converting Enzyme 1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 190 kDa
• Gene Name: angiotensin I converting enzyme
• Database Link:
  NP_000780
  Entrez Gene 11421 Mouse
  UniProt ID P12821
• Background: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
• Synonyms: ACE1; CD143; DCP; DCP1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Hypertrophic cardiomyopathy (HCM), Renin-angiotensin system