ATP citrate lyase (ACLY) Mouse Monoclonal Antibody [Clone ID: 3D9-E9-H8]

CAT#: TA346872

Mouse Monoclonal ATP-Citrate Lyase (C-terminus) Antibody

Specifications

Product Data

• Clone Name: 3D9-E9-H8
• Applications: FC, IF, WB
• Recommended Dilution: WB: 1:1000, IF: 1:150, FC: 1:100
• Reactivities: Human, Monkey, Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: The immunogen for ACLY antibody: purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 120 kDa
• Gene Name: ATP citrate lyase
• Database Link:
  NP_001087
  Entrez Gene 104112 MouseEntrez Gene 47 Human
  UniProt ID P53396
• Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
• Synonyms: ACL; ATPCL; CLATP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Citrate cycle (TCA cycle), Metabolic pathways