beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: 1H4-F5-C11]

CAT#: TA346886

Mouse Monoclonal beta Arrestin 1 Antibody

Product Images

Western blot detection of beta Arrestin 1 in PC12, Raw264.7, MCF7 and mouse brain cell lysates using beta Arrestin 1 mouse mAb (1:500 diluted).Predicted band size:50KDa.Observed band size:50KDa.

Specifications

Product Data

• Clone Name: 1H4-F5-C11
• Applications: WB
• Recommended Dilution: WB: 1:500
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for ARRB1 antibody: purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 50 kDa
• Gene Name: arrestin beta 1
• Database Link:
  NP_004032
  Entrez Gene 25387 RatEntrez Gene 109689 MouseEntrez Gene 408 Human
  UniProt ID P49407
• Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,neurotransmitters, or sensory signals.Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors.Besides the central nervous system,it is expressed at high levels in peripheral blood leukocytes,and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq,Jan 2011]
• Synonyms: ARB1; ARR1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Endocytosis, MAPK signaling pathway