HP1 gamma (CBX3) Mouse Monoclonal Antibody [Clone ID: 5G10-F7-A12]

CAT#: TA346904S

Mouse Monoclonal HP1-gamma Antibody

Specifications

Product Data

• Clone Name: 5G10-F7-A12
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:200
• Reactivities: Human, Monkey, Mouse, Hamster, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for CBX3 antibody: purified recombinant human HP1-gamma protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: chromobox 3
• Database Link:
  NP_009207
  Entrez Gene 11335 Human
  UniProt ID Q13185
• Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]
• Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma

Reference Data

• Protein Families: Druggable Genome, Transcription Factors