HP1 alpha (CBX5) Mouse Monoclonal Antibody [Clone ID: 3G2-H10-A6]

CAT#: TA346905

Mouse Monoclonal HP1 alpha Antibody

Specifications

Product Data

• Clone Name: 3G2-H10-A6
• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1:1000, IF: 1:300
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for CBX5 antibody: purified recombinant human HP1 alpha protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26 kDa
• Gene Name: chromobox 5
• Database Link:
  NP_036249
  Entrez Gene 12419 MouseEntrez Gene 23468 Human
  UniProt ID P45973
• Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Synonyms: HEL25; HP1; HP1A