p38 (CRK) Mouse Monoclonal Antibody [Clone ID: 3H7-E5-H8]

CAT#: TA346922

Mouse Monoclonal CrkII Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Clone Name 3H7-E5-H8
Applications WB
Recommended Dilution WB: 1:1000
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen The immunogen for CRK antibody: purified recombinant human CrkII protein fragments expressed in E.coli.
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 34 kDa
Gene Name v-crk avian sarcoma virus CT10 oncogene homolog
Background This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Synonyms CRKII; p38
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.