DCTN1 Mouse Monoclonal Antibody [Clone ID: 3D5-C6-D5]

CAT#: TA346929

Mouse Monoclonal Dynactin 1(N-terminus) Antibody

Product Images

Western blot analysis of Dynactin 1 in K562, MCF-7, 293T and Hela lysates using Dynactin 1 antibody.

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  Immunoprecipitation analysis of Dynactin Subunit 1 (3D5) in Hela lysates using Dynactin 1 antibody.

Specifications

Product Data

• Clone Name: 3D5-C6-D5
• Applications: IP, WB
• Recommended Dilution: WB: 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for DCTN1 antibody: purified recombinant Dynactin 1 protein fragments expressed in E.coli
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 150 kDa
• Gene Name: dynactin subunit 1
• Database Link:
  NP_004073
  Entrez Gene 1639 Human
  UniProt ID Q14203
• Background: This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
• Synonyms: DAP-150; DP-150; P135

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease