DCTN1 Mouse Monoclonal Antibody [Clone ID: 3D5-C6-D5]

CAT#: TA346929

Mouse Monoclonal Dynactin 1(N-terminus) Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

Product Images

Frequently bought together (2)
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Specifications

Product Data
Clone Name 3D5-C6-D5
Applications IP, WB
Recommended Dilution WB: 1:500
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen The immunogen for DCTN1 antibody: purified recombinant Dynactin 1 protein fragments expressed in E.coli
Formulation Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 150 kDa
Gene Name dynactin subunit 1
Background This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Synonyms DAP-150; DP-150; P135
Reference Data
Protein Families Druggable Genome
Protein Pathways Huntington's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.