elF2 alpha (EIF2S1) Mouse Monoclonal Antibody [Clone ID: 2E4-F5-E7]

CAT#: TA346937

Mouse Monoclonal eIF2a Antibody

Specifications

Product Data

• Clone Name: 2E4-F5-E7
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for EIF2S1 antibody: purified recombinant human eIF2a protein fragments expressed in E.coli.
• Formulation: PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: eukaryotic translation initiation factor 2 subunit alpha
• Database Link:
  NP_004085
  Entrez Gene 54318 RatEntrez Gene 1965 Human
  UniProt ID P05198
• Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
• Synonyms: EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A