FADD Mouse Monoclonal Antibody [Clone ID: 7C4-F12-F1]

CAT#: TA346944

Mouse Monoclonal FADD Antibody

Product Images

Western blot detection of FADD in A431 and Jurkat cell lysates using FADD mouse mAb (1:1000 diluted).Predicted band size:23KDa.Observed band size:23KDa.

Specifications

Product Data

• Clone Name: 7C4-F12-F1
• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for FADD antibody: purified recombinant human FADD protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23 kDa
• Gene Name: Fas associated via death domain
• Database Link:
  NP_003815
  Entrez Gene 8772 Human
  UniProt ID Q13158
• Background: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals.Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor,tumor necrosis factor receptor,TNFRSF25,and TNFSF10/TRAIL-receptor,and thus it participates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein,which allows it to recruit caspase-8,and thereby activate the cysteine protease cascade.Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq,Jul 2008]
• Synonyms: GIG3; MORT1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway