FEN1 Mouse Monoclonal Antibody [Clone ID: 7H8-F4-C11]

CAT#: TA346946

Mouse Monoclonal FEN-1 Antibody

Specifications

Product Data

• Clone Name: 7H8-F4-C11
• Applications: IF, WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Hamster, Human, Monkey, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for FEN1 antibody: purified recombinant human FEN-1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: flap structure-specific endonuclease 1
• Database Link:
  NP_004102
  Entrez Gene 14156 MouseEntrez Gene 84490 RatEntrez Gene 2237 Human
  UniProt ID P39748
• Background: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions. [provided by RefSeq,Jul 2008]
• Synonyms: FEN-1; MF1; RAD2

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Base excision repair, DNA replication, Non-homologous end-joining