Leptin (LEP) Mouse Monoclonal Antibody [Clone ID: 5C11-G6-B12]

CAT#: TA346994

Mouse Monoclonal Leptin Antibody

Product Images

Indirect ELISA assay for anti-Leptin mouse mAb.Antigen coating concentration: 4ug/ml.

Specifications

Product Data

• Clone Name: 5C11-G6-B12
• Applications: ELISA
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: The immunogen for LEP antibody: purified recombinant full length of human Leptin protein expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leptin
• Database Link:
  NP_000221
  Entrez Gene 3952 Human
  UniProt ID P41159
• Background: This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
• Synonyms: LEPD; OB; OBS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction