MLH1 Mouse Monoclonal Antibody [Clone ID: 2B3-H6-C11]

CAT#: TA347003

Mouse Monoclonal MLH1 Antibody

Product Images

Western blot detection of MLH1 in Hela, 293T and Jurkat cell lysates using MLH1 mouse mAb (1:500 diluted).Predicted band size:85KDa.Observed band size:85KDa.

Specifications

Product Data

• Clone Name: 2B3-H6-C11
• Applications: WB
• Recommended Dilution: WB: 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for MLH1 antibody: purified recombinant human MLH1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 85 kDa
• Gene Name: mutL homolog 1
• Database Link:
  NP_000240
  Entrez Gene 4292 Human
  UniProt ID P40692
• Background: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).It is a human homolog of the E. coli DNA mismatch repair gene mutL,consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described,but their full-length natures have not been determined. [provided by RefSeq,Nov 2009]
• Synonyms: COCA2; FCC2; hMLH1; HNPCC; HNPCC2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer