PPP1A (PPP1CA) Mouse Monoclonal Antibody [Clone ID: 1H1-F7-D8]

CAT#: TA347022

Mouse Monoclonal PPP1A Antibody

Specifications

Product Data

• Clone Name: 1H1-F7-D8
• Applications: IF, WB
• Recommended Dilution: WB: 1:1000, IF: 1:50
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for PPP1CA antibody: purified recombinant human PPP1A protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 37 kDa
• Gene Name: protein phosphatase 1 catalytic subunit alpha
• Database Link:
  NP_001008709
  Entrez Gene 5499 Human
  UniProt ID P62136
• Background: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: PP-1A; PP1A; PP1alpha; PPP1A

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Focal adhesion, Insulin signaling pathway, Long-term potentiation, Oocyte meiosis, Regulation of actin cytoskeleton, Vascular smooth muscle contraction