AMPK beta 1 (PRKAB1) Mouse Monoclonal Antibody [Clone ID: 1A7-E11-E9]

CAT#: TA347027

Mouse Monoclonal AMPK beta 1 Antibody

Specifications

Product Data

• Clone Name: 1A7-E11-E9
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:100
• Reactivities: Human, Monkey, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: The immunogen for PRKAB1 antibody: purified recombinant human AMPK beta 1 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: protein kinase AMP-activated non-catalytic subunit beta 1
• Database Link:
  NP_006244
  Entrez Gene 19079 MouseEntrez Gene 83803 RatEntrez Gene 695737 MonkeyEntrez Gene 5564 Human
  UniProt ID Q9Y478
• Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK).AMPK is a heterotrimer consisting of an alpha catalytic subunit,and non-catalytic beta and gamma subunits.AMPK is an important energy-sensing enzyme that monitors cellular energy status.In response to cellular metabolic stresses,AMPK is activated,and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR),key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.This subunit may be a positive regulator of AMPK activity.The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq,Jul 2008]
• Synonyms: AMPK; HAMPKb

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway