RPA34 (RPA2) Mouse Monoclonal Antibody [Clone ID: 3E7-B5-F2]

CAT#: TA347041

Mouse Monoclonal RPA32/RPA2 Antibody

Specifications

Product Data

• Clone Name: 3E7-B5-F2
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:2000, IF: 1:200
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for RPA2 antibody: purified recombinant human RPA32/RPA2 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 32 kDa
• Gene Name: replication protein A2
• Database Link:
  NP_002937
  Entrez Gene 6118 Human
  UniProt ID P15927
• Background: Required for DNA recombination,repair and replication.The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
• Synonyms: REPA2; RP-A p32; RP-A p34; RPA32

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair