RPA70 (RPA1) Mouse Monoclonal Antibody [Clone ID: 8C3-D12-H10]
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Recombinant protein of human replication protein A1, 70kDa (RPA1)
USD 823.00
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Specifications
Product Data | |
Clone Name | 8C3-D12-H10 |
Applications | IF, IP, WB |
Recommended Dilution | WB: 1:1000, IF: 1:100 |
Reactivities | Human, Monkey, Mouse, Rat |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | The immunogen for RPA70 antibody: purified recombinant human RPA70 protein fragments expressed in E.coli. |
Formulation | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol. |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 70 kDa |
Gene Name | replication protein A1 |
Database Link | |
Background | Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. |
Synonyms | HSSB; MST075; REPA1; RF-A; RP-A; RPA70 |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
Protein Pathways | DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair |
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