RPA70 (RPA1) Mouse Monoclonal Antibody [Clone ID: 8C3-D12-H10]

CAT#: TA347042

Mouse Monoclonal RPA70 Antibody

Specifications

Product Data

• Clone Name: 8C3-D12-H10
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:100
• Reactivities: Human, Monkey, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: The immunogen for RPA70 antibody: purified recombinant human RPA70 protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 70 kDa
• Gene Name: replication protein A1
• Database Link:
  NP_002936
  Entrez Gene 68275 MouseEntrez Gene 287524 RatEntrez Gene 6117 Human
  UniProt ID P27694
• Background: Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
• Synonyms: HSSB; MST075; REPA1; RF-A; RP-A; RPA70

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair