TAB1 Mouse Monoclonal Antibody [Clone ID: 3D10-G10-B6]

CAT#: TA347060

Mouse Monoclonal TAB1(N-terminus) Antibody

Product Images

Western blot detection of TAB1 (N-terminus) in K562 and Hela lysates using TAB1 (N-terminus) mouse mAb (1:1000 diluted).Predicted band size: 55KDa.Observed band size: 55KDa.

Specifications

Product Data

• Clone Name: 3D10-G10-B6
• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Immunogen: The immunogen for TAB1 antibody: purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
• Formulation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 55 kDa
• Gene Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
• Database Link:
  NP_006107
  Entrez Gene 10454 Human
  UniProt ID Q15750
• Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported
• Synonyms: 3 -Tab1; 3'-Tab1; MAP3K7IP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway